A train derailment in the early morning hours of Tuesday in the Missouri bootheel closes a state highway. “US62 West near ...

Roughly 10 years ago, Missouri Rep. Tricia Byrnes’ son, Chase, was diagnosed with a rare form of cancer. Shocked by his ...

A train derailed on Highway 62 West, about 3 miles west of Campbell in Dunklin County, on Tuesday morning, the Campbell Fire ...

Here are holiday events to enjoy this week in the St. Louis area. Tour participants will ride a horse-drawn carriage at Elsah ...

Contributed Darius Watson, executive director of academic initiatives at Lincoln University, teaches a class on espionage to ...

The trail is mercifully flat and well-maintained, making it accessible to day-trippers of all fitness levels, from spandex-clad enthusiasts on carbon-fiber racing machines to casual visitors in ...

ST. LOUIS, Mo. ( 25News Now and First Alert 4) - An Amtrak train that left St. Louis for Chicago around 8 a.m. Sunday was ...

An Amtrak train that left St. Louis for Chicago around 8 a.m. Thursday was disabled en route and could not complete the trip, ...

A major fire involving several historic warehouses occurred in downtown St. Louis, with over 200 firefighters responding to a ...

Firefighters are battling a large multi-warehouse fire that started early Friday morning in a cluster of warehouses just ...

St. Louis Premium Outlets stands as Missouri’s monument to the art of the deal, where brand names and bargain prices coexist in beautiful harmony. Let’s be honest – shopping at regular retail prices ...

"Who knew people in small towns do this for fun?" said club member Julie Gates.