Ence's Prediction: Jacksonville takes care of business in Arizona.

Let's take a look at four things to know about Jaguars vs. Cardinals along with a prediction for the Week 12 game.

The Cardinals added three players to the active roster ahead of a Jaguars matchup on Sunday, while Jacksonville activated a tight end from injured reserve.

Watch the Jacksonville Jaguars' final practice of the week before they take on the Arizona Cardinals in Week 12.

The Jacksonville Jaguars are heading to the West Coast to face the Arizona Cardinals in Week 12 of the 2025 NFL Season. The game will kick off at 4:05 p.m. ET at State Farm Stadium. Catch up on all the action, behind-the-scenes moments, and full game coverage. ⬇️

The Arizona Cardinals have played the Jacksonville Jaguars just six times in their history, tied for their fewest games against any team.

A look at what the Jaguars did the game after winning by at least 29 points. Plus, about Lane Kiffin's upcoming decision.

The Jacksonville Jaguars will be without some important names when they take on the Arizona Cardinals in Week 12.