Mixon isn't expected to play at all this year, per NFL Media. It's a shocking turn of events for someone who was voted to the Pro Bowl in 2024 during his first season in Houston. Texans general manager Nick Caserio was actually asked about Mixon's injury this week, and at the time, he gave an ominous update on the running back's health.

The Houston Texans are gearing up to face the Buffalo Bills for an electric Thursday Night Football matchup, but some unfortunate news dropped just hours before