Ence's Prediction: Jacksonville takes care of business in Arizona.

The Jaguars are 5-4-1 against the spread, while the Cardinals are 5-5 ATS. Arizona has the 14th-best offense and 21st best defense, while Jacksonville has the 19th-best offense and14th-best defense. The SportsLine model projects one side of the spread has all the value. Jaguars vs. Cardinals score prediction: Jaguars 26, Cardinals 23

Let's take a look at four things to know about Jaguars vs. Cardinals along with a prediction for the Week 12 game.

Learn which TV channel or how to live stream the NFL Week 12 Arizona Cardinals and Jacksonville Jaguars game, Sunday, Nov. 23.

The Jacksonville Jaguars activated tight end Brenton Strange from injured reserve on Saturday, paving the way for him to play Sunday against the Arizona Cardinals. Strange had missed the past five games because of a hip injury he suffered in the Jaguars' Week 5 victory over Kansas City.

A look at what the Jaguars did the game after winning by at least 29 points. Plus, about Lane Kiffin's upcoming decision.

There will no return to the field for Arizona Cardinals running back Trey Benson this week. Designated to return on Wednesday from injured reserve and able to practice for the first time since he suffered a knee injury in Week 4, Benson was ruled out of Sunday's game against the Jacksonville Jaguars at State Farm Stadium in Week 12.